abstract：:In the literature, few studies analyze the effect of GH therapy on height, preferring a more indirect approach, where factors influencing the total pubertal and pre-pubertal growth in GH-deficient patients are evaluated and subsequently used to estimate the overall effect at the end of the therapy; unfortunately, this...

journal_title：Journal of endocrinological investigation

authors： Migliaretti G,Berchialla P,Borraccino A,Gregori D,Cavallo F,Commissione GH Piemonte.

更新日期：2012-02-01 00:00:00

abstract：AIM:To evaluate if nutritional intakes and lipid profile fulfill international guidelines and recommendations before and after a structured dietician training to a Mediterranean- style diet in an Italian pediatric population with Type 1 diabetes. METHODS:A 6-month prospective cohort study. Baseline and after-intervent...

journal_title：Journal of endocrinological investigation

authors： Cadario F,Prodam F,Pasqualicchio S,Bellone S,Bonsignori I,Demarchi I,Monzani A,Bona G

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Subtotal parathyroidectomy (SP) and total parathyroidectomy (TP) with autotransplantation (TPai) are the most commonly adopted operations for the treatment of secondary hyperparathyroidism (2HPT). TP without autotransplantation had previously been confined to patients with advanced dialytic vintage, not elig...

journal_title：Journal of endocrinological investigation

authors： Conzo G,Perna AF,Sinisi AA,Palazzo A,Stanzione F,Della Pietra C,Livrea A

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To determine whether glycated hemoglobin (HbA1c) could be used to diagnose Type 2 diabetes mellitus in She Chinese People and to assess the role of HbA1c in the development of cardiovascular disease. RESEARCH DESIGN AND METHODS:An ethnically representative sample of 687 (277 males and 410 females) adults, 20...

journal_title：Journal of endocrinological investigation

authors： Lin Y,Xu Y,Chen G,Huang B,Chen Z,Yao L,Chen Z

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND AIM:There is limited data on the effects of inactivity (prolonged bed-rest) on parameters of endocrine and metabolic function; we therefore aimed to examine changes in these systems during and after prolonged (56- day) bed-rest in male adults. SUBJECTS AND METHODS:Twenty healthy male subjects underwent ...

journal_title：Journal of endocrinological investigation

authors： Belavý DL,Seibel MJ,Roth HJ,Armbrecht G,Rittweger J,Felsenberg D

更新日期：2012-01-01 00:00:00

abstract：:Seventy years after the first successful radioiodine treatment of metastatic differentiated thyroid cancer (DTC), radioiodine (131I) therapy for this type of tumor is still without alternative. During the last decade, some key issues such as individual dosimetry, and preparation of 131I therapy by recombinant human TS...

journal_title：Journal of endocrinological investigation

authors： Luster M,Hänscheid H,Freudenberg LS,Verburg FA

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:In vitro islet expansion has recently drawn interest for its potential application in diabetes therapy, while how islet cells adapt to in vitro circumstances is not quite clear. AIM:Proteomics changes of cultivated islet cells under different conditions were examined in this study. MATERIAL/SUBJECTS AND ME...

journal_title：Journal of endocrinological investigation

authors： Li G,Yang X,Zhang Y,Liu H,Zhang W,Shen Y,Fan W,Lu Z,Lu D

更新日期：2011-12-01 00:00:00

abstract：:Resveratrol, the naturally occurring polyphenolic compound characterized by anti-oxidative, anti-inflammatory and apoptotic properties, appears to contribute substantially to cardioprotection and cancer-prevention. In addition, resveratrol is believed to regulate several biological processes, mainly metabolism and agi...

journal_title：Journal of endocrinological investigation

authors： Duntas LH

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:Blood endothelial progenitor cells (EPC) and microparticles (EMP) have been proposed as markers of endothelial dysfunction. Aim of this study was to evaluate a new immunophenotype of EPC and EMP in patients with arterial erectile dysfunction (AED) compared to psychogenic erectile dysfunction (PED). MATERIALS...

journal_title：Journal of endocrinological investigation

authors： La Vignera S,Condorelli R,Vicari E,D'Agata R,Calogero AE

更新日期：2011-11-01 00:00:00

abstract：:Liquid-chromatography - tandem mass spectrometry (LC-MS/MS) is becoming the method of choice for clinical steroid analysis. In most instances, it has the advantage of higher sensitivity, better reproducibility and greater specificity than commercial immunoassay techniques. The method requires only minimal sample prepa...

journal_title：Journal of endocrinological investigation

authors： Kulle AE,Welzel M,Holterhus PM,Riepe FG

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:Carcinoids are mainly found in the gastrointestinal (65%) and bronchopulmonary tract (25%). These neuroendocrine tumors secrete a wide range of bioactive peptides, including gastrin releasing peptide and neuromedin B, the mammalian analogs of bombesin. The purpose of this study was to investigate the quant...

journal_title：Journal of endocrinological investigation

authors： Kuiper P,Verspaget HW,Biemond I,de Jonge-Muller ES,van Eeden S,van Velthuysen ML,Taal BG,Lamers CB

更新日期：2011-10-01 00:00:00

abstract：:Non-classical congenital adrenal hyperplasia (NCAH) is a morbid condition sustained by the reduced function of one of the enzymes involved in the adrenal steroid biosynthesis pathway, mainly the 21-hydroxylase. Different degrees of enzyme activity impairment determine different clinical pictures, with childhood or pos...

journal_title：Journal of endocrinological investigation

authors： Einaudi S,Napolitano E,Restivo F,Motta G,Baldi M,Tuli G,Grosso E,Migone N,Menegatti E,Manieri C

更新日期：2011-10-01 00:00:00

abstract：:Measurement of serum Tg using ultrasensitive assays is proposed to replace TSH-stimulated Tg measurement in the follow-up of differentiated thyroid cancer (DTC). Aim of our study was to verify this possibility using two ultrasensitive Tg assays. We selected 215 DTC patients with undetectable (<1 ng/ml) basal serum Tg ...

journal_title：Journal of endocrinological investigation

authors： Castagna MG,Tala Jury HP,Cipri C,Belardini V,Fioravanti C,Pasqui L,Sestini F,Theodoropoulou A,Pacini F

更新日期：2011-09-01 00:00:00

abstract：:Traumatic brain injury (TBI)-induced hypopituitarism remains a relevant medical problem, because it may affect a significant proportion of the population. In the last decade important studies have been published investigating pituitary dysfunction after TBI. Recently, a group of experts gathered and revisited the topi...

journal_title：Journal of endocrinological investigation

authors： Tanriverdi F,Agha A,Aimaretti G,Casanueva FF,Kelestimur F,Klose M,Masel BE,Pereira AM,Popovic V,Schneider HJ

更新日期：2011-07-01 00:00:00

abstract：:Vitamin D via its receptor has essential actions on parathyroid cells, inhibiting PTH secretion, and parathyroid cell proliferation. While the effects of vitamin D depletion in the pathogenesis of secondary hyperparathyroidism in elderly individuals or in the occurrence of parathyroid hyperplasia in patients with rena...

journal_title：Journal of endocrinological investigation

authors： Nuti R,Merlotti D,Gennari L

更新日期：2011-07-01 00:00:00

abstract：AIMS:To investigate the prevalence of metabolic syndrome and its components in both rural and urban Chinese population. SUBJECTS AND METHODS:A population-based crosssectional survey was conducted in Qingdao, China in 2006 with 6100 Chinese aged 35-74 yr invited and 5355 who attended; 3357 subjects, 1562 urban (46.5%) ...

journal_title：Journal of endocrinological investigation

authors： Zhao J,Pang ZC,Zhang L,Gao WG,Wang SJ,Ning F,Nan HR,Ren J,Qiao Q,Qingdao 2006 Diabetes Survey Group.

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Energy homeostasis and body weight are regulated by a highly complex network involving the brain, the digestive tract, and white adipose tissue (WAT). Knowledge about signaling pathways connecting digestive tract and WAT is limited. Gut hormone ghrelin and adipokine adiponectin are both decreased in obesity ...

journal_title：Journal of endocrinological investigation

authors： Kiewiet RM,Hazell MJ,van Aken MO,van der Weerd K,Visser JA,Themmen AP,van der Lely AJ

更新日期：2011-06-01 00:00:00

abstract：AIM:The optimal GH regimen, in terms of cost-effectiveness, in children with normal GH immunoreactivity but reduced bioactivity is still debated. METHODS:In 12 GH-deficient (GHD) and 12 bioinactive GH children undergoing GH treatment we evaluated the increase in growth velocity, the difference between target height an...

journal_title：Journal of endocrinological investigation

authors： Pagani S,Meazza C,Laarej K,Cantoni F,Bozzola M

更新日期：2011-05-01 00:00:00

abstract：:The aim of this prospective study was to investigate the effects of thyroid hormone levels on the sepsis criteria and mortality in septic newborns. This study was performed at the Firat University Hospital Neonatal Intensive Care Unit. A group of septic newborns and a control group of healthy non-infected newborns wer...

journal_title：Journal of endocrinological investigation

authors： Kurt A,Aygun AD,Sengul I,Sen Y,Citak Kurt AN,Ustundag B

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Thyroid gland is highly dependent on dietary intake of iodine for normal function, so it is particularly subjected to "endocrine disruptor" action. The human sodium/iodide symporter (hNIS) is an integral plasma membrane glycoprotein mediating the active transport of iodide into thyroid follicular cells, a cr...

journal_title：Journal of endocrinological investigation

authors： Agretti P,Dimida A,De Marco G,Ferrarini E,Rodrìguez Gonzàlez JC,Santini F,Vitti P,Pinchera A,Tonacchera M

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The coexistence of insulin and ACTH hypersecretion in the same patient is extremely rare. A diabetic patient with a pancreatic endocrine tumor (PET) co-secreting insulin and ACTH is even rarer and has never been described. The combination of these two endocrine syndromes results in a peculiar clinical pictur...

journal_title：Journal of endocrinological investigation

authors： Filippella M,Davì MV,Doveri G,Lillaz E,Ciccarelli A,Massimetti E,Toaiari M,Falconi M,Colao A,Faggiano A

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:In contrast with maximal voluntary resistance exercise, which is allegedly considered a potent GH stimulus in young subjects, evaluation of GH response to whole-body vibrations (WBV) has yielded conflicting results. METHODS:The acute effects of WBV alone (test A), maximal voluntary isometric contractions (M...

journal_title：Journal of endocrinological investigation

authors： Sartorio A,Agosti F,De Col A,Marazzi N,Rastelli F,Chiavaroli S,Lafortuna CL,Cella SG,Rigamonti AE

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Adiponectin has emerged over the last decade as a key adipokine linking obesity, insulin resistance, and Type 2 diabetes. However, the molecular mechanisms controlling adiponectin expression in adipose tissue are not fully elucidated. Furthermore, increasing evidence indicates that peroxisome proliferator-ac...

journal_title：Journal of endocrinological investigation

authors： Kouidhi S,Jarboui S,Marrakchi R,Froidevaux MS,Seugnet I,Abid H,Bchir F,Brahem M,Demeneix B,Guissouma H,Elgaaied AB

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Adipose tissue has been suggested to influence bone density and metabolism through the effect of some adipokines. However, whether adiponectin and visfatin may correlate with bone metabolism is still unclear. AIM:The aim of this study was to investigate the relationship of adiponectin and visfatin with bone...

journal_title：Journal of endocrinological investigation

authors： Iacobellis G,Iorio M,Napoli N,Cotesta D,Zinnamosca L,Marinelli C,Petramala L,Minisola S,D'Erasmo E,Letizia C

更新日期：2011-01-01 00:00:00

abstract：:The research suggests that adiponectin plays an important role in sensitizing insulin action. It is interesting to find that the lower levels of adiponectin exist in the plasma of obese and Type 2 diabetes subjects and in the adipose tissue of obese, db/db mice, and insulin-resistant individuals. However, the underlyi...

journal_title：Journal of endocrinological investigation

authors： Sun S,Liu Y,Lu J,Omar A,Sun S,Bi Y,Wang C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND AIM:Familial adenomatous polyposis (FAP) is an autosomal inherited syndrome characterized by hundreds to thousands colorectal adenomatous polyps with oncological transformation lifetime risk of 100%. FAP is mainly associated with mutations in APC (autosomal dominant inheritance) or MUTYH (autosomal reces...

journal_title：Journal of endocrinological investigation

authors： Martayan A,Sanchez-Mete L,Baldelli R,Falvo E,Barnabei A,Conti L,Giacomini P,Appetecchia M,Stigliano V

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Acromegaly is known to be associated to vascular damage characterized by an increase of vascular wall thickness and an impairment of vascular function. AIM:The aim of this study was to evaluate the effect of medical treatment with the GH receptor antagonist pegvisomant on vascular structure and function in ...

journal_title：Journal of endocrinological investigation

authors： De Martino MC,Auriemma RS,Brevetti G,Vitale G,Schiano V,Galdiero M,Grasso L,Lombardi G,Colao A,Pivonello R

更新日期：2010-10-01 00:00:00

abstract：UNLABELLED:The aim of this study was to assess the behaviour of insulin sensitivity and insulin resistance (IR) indexes in a group of obese adolescents with Type 2 diabetes mellitus (T2DM) in comparison to obese adolescents without diabetes and normal controls, moreover to compare these parameters with the cardiac auto...

journal_title：Journal of endocrinological investigation

authors： Cerutti F,Rabbia F,Rabbone I,Bobbio A,Ignaccolo MG,Greco G,Bertello MC,Mulatero P,Veglio F,Pacini G

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIMS:Aldosterone and the mineralocorticoid receptor (MR) play a major role in sodium balance and blood pressure control. They are also involved in adipocyte metabolism. The aim of this study was to analyze the association between the MR p.I180V polymorphism with hypertension and markers of cardiovascular ris...

journal_title：Journal of endocrinological investigation

authors： Fernandes-Rosa FL,Bueno AC,de Souza RM,de Castro M,dos Santos JE,Foss MC,Zennaro MC,Bettiol H,Barbieri MA,Antonini SR

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Protein tyrosine phosphatase (PTP)- 1B, encoded by the PTPN1 gene, negatively regulates insulin signaling by dephosphorylating the phosphotyrosine residues of the insulin receptor kinase activation segment. Several rare single nucleotide polymorphisms (SNP) have been linked to diseases accompanying insulin r...

journal_title：Journal of endocrinological investigation

authors： Gu P,Jiang W,Du H,Shao J,Lu B,Wang J,Zou D

更新日期：2010-07-01 00:00:00

abstract：:Short stature homeobox-containing (SHOX) gene mutations causing haploinsufficiency have been reported in idiopathic short stature, but the real prevalence of this defect in the population with growth failure is debated. Based on current data, the prevalence of SHOXdefect (SHOX-D) has been calculated to have occurred i...

journal_title：Journal of endocrinological investigation

authors： Cicognani A,Pirazzoli P,Nicoletti A,Baronio F,Conti V,Bonetti S

更新日期：2010-06-01 00:00:00

abstract：:The occurrence of metabolic bone disease in patients with renal dysfunction is due to the key role played by the kidney in regulating calcium-phosphate metabolism. The incidence of hip fractures in end-stage renal disease is 3- to 4-fold higher than the general population, while poor data about vertebral fractures sho...

journal_title：Journal of endocrinological investigation

authors： Fusaro M,D'Angelo A,Scalzo G,Gallieni M,Giannini S,Guglielmi G

更新日期：2010-05-01 00:00:00

abstract：:American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules are systematically developed statements to assist health care professionals in medical decision making for ...

journal_title：Journal of endocrinological investigation

authors： Gharib H,Papini E,Paschke R,Duick DS,Valcavi R,Hegedüs L,Vitti P,AACE\/AME\/ETA Task Force on Thyroid Nodules.

更新日期：2010-01-01 00:00:00

abstract：:Bone matrix is composed mainly of inorganic materials, while the bone organic compartment is a minor and complex structural entity, surrounding and supporting cells. Three major classes of biomolecules are involved in this organic part: structural proteins, specialized proteins, and proteoglycans. This review will bri...

journal_title：Journal of endocrinological investigation

authors： Camozzi V,Vescini F,Luisetto G,Moro L

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Agents capable of increasing radioiodine concentration by stimulating the sodium/iodide symporter (NIS) expression have been extensively investigated for the treatment of certain well-differentiated breast cancers. AIM:In this study, we analyzed the regulation of the NIS and lactoperoxidase (LPO) gene expre...

journal_title：Journal of endocrinological investigation

authors： Sponziello M,Scipioni A,Durante C,Verrienti A,Maranghi M,Giacomelli L,Ferretti E,Celano M,Filetti S,Russo D

更新日期：2010-01-01 00:00:00

abstract：:Glucocorticoid over-treatment in children with congenital adrenal hyperplasia (CAH) may suppress GH secretion and growth. Aims of our study were: 1) to evaluate post-exercise GH response in patients affected by CAH due to 21-hydroxylase deficiency, in comparison with a group of healthy subjects; 2) to investigate the ...

journal_title：Journal of endocrinological investigation

authors： Bizzarri C,Ubertini G,Crea F,Colabianchi D,Loche S,Ravà L,Cappa M

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Although two studies have shown that Addison's disease (AD) is still a potentially lethal condition for cardiovascular, malignant, and infectious diseases, a recent retrospective study showed a normal overall mortality rate. Differently from secondary hypoadrenalism, scanty data exist on the role of conventio...

journal_title：Journal of endocrinological investigation

authors： Giordano R,Marzotti S,Balbo M,Romagnoli S,Marinazzo E,Berardelli R,Migliaretti G,Benso A,Falorni A,Ghigo E,Arvat E

更新日期：2009-12-01 00:00:00

abstract：:Human amniotic fluid (HAF) contains multipotent stem cells [amniotic fluid-derived stem cells (AFSC)] which can differentiate into a variety of different cell types. Recently, we demonstrated that obestatin, a peptide encoded by the ghrelin gene, exerts anti-apoptotic effects in pancreatic beta-cells and human islets ...

journal_title：Journal of endocrinological investigation

authors： Trovato L,De Fazio R,Annunziata M,Sdei S,Favaro E,Ponti R,Marozio L,Ghigo E,Benedetto C,Granata R

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:Aim of this study is to report on basal clinical phenotype and follow up after diagnosis, of patients with 17beta-hydroxysteroid-dehydrogenase type 3 (17beta-HSD3) deficiency in Italy. SETTING:Pediatric Endocrine Departments, University Hospitals. PATIENTS:The cases of 5 Italian subjects affected by 17beta-...

journal_title：Journal of endocrinological investigation

authors： Bertelloni S,Balsamo A,Giordani L,Fischetto R,Russo G,Delvecchio M,Gennari M,Nicoletti A,Maggio MC,Concolino D,Cavallo L,Cicognani A,Chiumello G,Hiort O,Baroncelli GI,Faienza MF

更新日期：2009-09-01 00:00:00

abstract：:The prevalence of primary aldosteronism has increased since many patients who were previously considered as being affected by low renin essential hypertension are actually satisfying the new diagnostic criteria using plasma aldosterone/ plasma renin activity (PRA) ratio. Many of these cases could be classified as subc...

journal_title：Journal of endocrinological investigation

authors： Armanini D,Fiore C

更新日期：2009-07-01 00:00:00